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Familial Parkinson’s caused by new gene

Wednesday April 20, 2005

4/12/05(Newswise) - The newest gene for Parkinson’s disease, LRRK2, is proving to be a very common cause of familial PD.

Recent studies have shown it is responsible for up to 6 percent of familial cases in North America and Europe.

In this study, researchers found that 41 percent of autosomal dominant PD in North African patients were due to a single mutation in the gene, which is also the most common mutation in other populations.

As has been seen in other populations, younger mutation carriers were less likely to be affected, indicating the existence of age-dependant penetrance for the gene mutation.